Hypothesis

 


 Update (Jan 8, 2014): Evidence Live 2015. April 14 and 15, Examination Schools Conference Centre, University of Oxford.

“Evidence Live is a partnership between The BMJ and the Centre for Evidence-Based Medicine in the University of Oxford’s Nuffield Department of Primary Care Health Sciences.” – http://evidencelive.org/

The three submitted abstracts were “deemed to be of high quality” by the Conference Planning Committee.

―Analysis of US phase 3 ClinicalTrials.gov records completed before January 1st, 2011 (n=5051; time frame: 2002 to 2014): has been accepted as a 15 minute (10 +5) oral presentation.

―Basic and clinical pharmacology of the “uroselective” α blocker tamsulosin: a critical analysis: has been accepted as a poster.

―Hierarchical levels of evidence based medicine are incorrect: accepted as a poster.



 

Update (Dec 17, 2014)―Null hypothesis formally rejected. Evidence based medicine (EBM) not evidence-based: medicine is broken. 



Update (Dec 15, 2014)―Null hypothesis rejected.



Update (Dec 7, 2014): Data (i.e., evidence) about evidence-based medicine. Via blog or figshare.




Original post on this blog (Nov 6, 2014)

a b


Hypothesis: Hierarchical levels of evidence based medicine are wrong

Dear Editor,

I have data to support the hypothesis described in the title of this letter.

Before rejecting the null hypothesis I would like to ask the following open question:
Could you support with data that hierarchical levels of evidence based medicine are correct? (1,2)

Additional explanation to this question:

– Only respond to this question attaching publicly available raw data.
– Be aware that more than a question this is a challenge: I have data (i.e., evidence) which is contrary to classic (i.e., McMaster) or current (i.e., Oxford) hierarchical levels of evidence based medicine. An important part of this data (but not all) is publicly available.

References

1. Ramirez, Jorge H (2014): The EBM challenge. figshare.
http://dx.doi.org/10.6084/m9.figshare.1135873

2. The EBM Challenge Day 1: No Answers.

Competing interests: I endorse the principles of open data in human biomedical research.

Read this letter on The BMJ – August 13, 2014. | Re: Greenhalgh T, et al. Evidence based medicine: a movement in crisis? BMJ 2014; 348: g3725.



Addendum:

The hypothesis about hierarchical levels of evidence based medicine was the main reason to create this blog about 4 months ago (Aug, 10, 2014 – 3 days before submitting the BMJ letter). A blog is not the proper place to discuss data concerning any research hypothesis. Nonetheless, I will continue informing about any updates in this blog (i.e., papers accepted or rejected). For now, I prefer to practice some moderation (science must pass the test of pre-publication and post-publication peer-review).

Part of this evidence (disclosed at a raw data level) have been published in The BMJ as letters to the editor (i.e., rapid responses) and some comments at PubMed Commons.
– view the complete list via Impactstory.org

Additional data (raw level) is also available on my figshare public profile.

Below you will find a list of earlier posts related to the hypothesis. Finally, I would like to quote a phrase from my first post (Welcome to my blog: Chaos Theory and Human Pharmacology – Aug 10, 2014).

“I don’t have a detailed plan for future postings, I cannot predict the unpredictable, I only promise that this blog will be chaotic…”

I still do not have a plan for future postings.

Response to J. Castellani  PhRMA   An ounce of data  i.e., 64740 data values    Chaotic Pharmacology Welcome to my blog  Chaos Theory and Human Pharmacology   Chaotic Pharmacology (1)   Chaotic Pharmacology   A blog dedicated to the study of complex relationships in human pharmacology   Chaos theory; nonlinear models; nonlinear dynamics (1)

Meta-analysis provide the best strength of evidence about medical interventions  are you sure    Chaotic PharmacologyChaotic Pharmacology   A blog dedicated to the study of complex relationships in human pharmacology   Chaos theory; nonlinear models; nonlinear dynamicsMeta-analysis provide the best strength of evidence about medical interventions  are you sure    Chaotic Pharmacology (1)

Chaos begins in this blog

Lorenz Attractor Generative Piece made in Processing.org   Flickr - Photo Sharing! (1)

                                                                    “Chaos Theory” to “Evidence Based Medicine”   1  Hello!   Chaotic Pharmacology The EBM Challenge  Day 2 . Hypothesis  hierarchical levels of evidence based medicine are wrong  BMJ Letter. Aug 13, 2014    Chaotic Pharmacology

I do not have any sponsorship or research grant to hire data collectors, statisticians, and writers.

Jorge Ramírez  @Jor_H_R    Twitter (1)

I do not have a “pubplan” & I am strongly against ghostwriting

ghostbusters_logo-svg-1

PLoS Ghostwriting Collection

I am also NOT interested in obtaining a research grant to test this hypothesis, BUT if you are a researcher (with or without experience in this field) willing to be involved in any way (e.g., learning, proposing different approaches to data analysis, guide me, scrutinize raw data, reviewing  – confidentially – my working papers) please contact me

m

If you are an undergraduate in medicine, statistics, chemistry, mathematics (not limited to these fields of knowledge) motivated to take part in this research: please contact me.

If you are a postgraduate student (research fellow, MS, PhD) looking for a thesis: please contact me.

  1 comment for “Hypothesis

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: