Category: Transparency

Evidence Live 2015: Analysis of US phase 3 ClinicalTrials.gov records completed before January 1st, 2011 (n=5051; time frame: 2002 to 2014).

Introduction (background) There has been a growing concern about the selective reporting of clinical trial results (i.e., publication bias). The problem of unpublished and misreported clinical trials was the main reason behind the creation of campaigns such as AllTrials and The BMJ Open Data Campaign. The birth of clinical trial registers (e.g., ClinicalTrials.gov, EudraCT, ISCRTN,…

Update: Data (i.e., evidence) about evidence based medicine.

Future updates:  http://chaoticpharmacology.com/hypothesis/ http://dx.doi.org/10.6084/m9.figshare.1093997   Update (Jan 8, 2014): Evidence Live 2015. April 14 and 15, Examination Schools Conference Centre, University of Oxford. “Evidence Live is a partnership between The BMJ and the Centre for Evidence-Based Medicine in the University of Oxford’s Nuffield Department of Primary Care Health Sciences.” – http://evidencelive.org/ The three submitted abstracts were…

Addictions

New page: http://chaoticpharmacology.com/addictions/ View on TED website: http://www.ted.com/talks/ethan_nadelmann_why_we_need_to_end_the_war_on_drugs     View on TED website: http://www.ted.com/talks/rodrigo_canales_the_deadly_genius_of_drug_cartels   PharmaGossip – Nov 5, 2014: “Watch to the end please” Note: full version of this video is not longer available on YouTube (sorry).         Drug policy: we probably need an “irrational authority” ―Letter to The BMJ “One thing…

Three shells and a pea–ASAM, FSPHP, and LMD

Originally posted on Disrupted Physician:
She likes a rigged game, you know what I mean?” — R.P. Murphy in Ken Kesey’s One Flew Over the Cuckoo’s Nest ? Published  in the March 17, 2014 newsletter Alcoholism and Drug Abuse Weekly, an article  entitled “Physician group urges focus on spiritual and psychosocial” describes a group of doctors…

Re: Are clinical trial data shared sufficiently today? Yes

Read this letter on The BMJ: Response to J. Castellani (PhRMA): An ounce of data (i.e., 64740 data values). Response to: Castellani John. Are clinical trial data shared sufficiently today? Yes BMJ 2013; 347:f1881 Related posts: Welcome to my blog: Chaos Theory and Human Pharmacology (time is relative) Evidence Live 2015: Analysis of US phase 3 ClinicalTrials.gov…

Dr. David Healy: “paroxetine doesn’t work and isn’t safe.”

“paroxetine doesn’t work and isn’t safe.” ―David Healy. http://davidhealy.org/persecution-dangerous-liaisons/ Re: Agreed. — Response to: “Full text of CEP members’ letter to The Lancet Psychiatry in response to article by Nutt et al” —Council for Evidence-based Psychiatry  — Ramirez, Jorge H (2014): Paroxetine: analysis of unpublished human studies (observationals and clinical trials). figshare. http://dx.doi.org/10.6084/m9.figshare.1103284  Sincerely, Jorge H. Ramírez. “Persecution: Dangerous Liaisons”…

“Sharing Clinical Trial Data: Maximizing Benefits, Minimizing Risk” –Institute of Medicine (IOM)

“Although clinical trials generate vast amounts of data, a large por­tion is never published or made available to other researchers. Data sharing could advance scientific discovery and improve clinical care by maximizing the knowl­edge gained from data collected in trials, stimulating new ideas for research, and avoiding unnecessarily duplicative trials. In response to 23 public- and…

Red or blue pill?

“Próximo curso de farmacológia no tendra clase de antidepresivos – los temas de psiquiatría seran condensados a una o varias sesiones de discusión sobre la real eficacia y seguridad de estos medicamentos. La industria farmacéutica le miente a los médicos, los profesores de básicas (farmacología) y especialidades clínicas son una plataforma para diseminar las mentiras…

Are large clinical trials (phase 3) of experimental cancer therapies sufficiently disclosed? No

I honestly want to be wrong about the following statement: Over 60% of phase 3 clinical trials testing interventions in humans patients with cancer are unpublished –> 3y and 11m after the study completion date. Open data (raw-level): please feel free to scruitinize it. – http://dx.doi.org/10.6084/m9.figshare.1255059 – https://docs.google.com/document/d/1BeZXev9UDJkfsSLo03RhA0Q7lutU9uTwKcNWUVP-Jrc/edit?usp=sharing Analysis of these databases will be continuously updated.   Featured…