Category: Evidence

Análisis escéptico del escepticismo (*)

 “Si la investigación científica va a dictar cuándo un tratamiento farmacológico tiene efectos adversos o no, más nos vale permitir toda la crítica posible en este campo.” Autor: Marc Casañas. Publicado originalmente ayer (Mayo 23, 2016) en la página web de la plataforma NoGracias. — Habiendo comentado recientemente Abel Novoa la necesidad de una aproximación…

The Lost Children (2015) – @AntiDepAware

— [ . . . ] “Are there really people of influence in our Health Service and our Coronial System who consider that protecting the identity of psychiatric drugs should take precedence over protecting our children?” [ . . . ] Read more: http://antidepaware.co.uk/the-lost-children-2015/ Re: Dear Brian, All I can say is: 1. The contents…

Safety and efficacy of hysteroscopic sterilization (#Essure) compared with laparoscopic sterilization – The BMJ (*)

Mao Jialin, Pfeifer Samantha, Schlegel Peter,Sedrakyan Art. Safety and efficacy of hysteroscopic sterilization compared with laparoscopic sterilization: an observational cohort study 2015;351 :h5162. BMJ 2015;351:h5162 doi: 10.1136/bmj.h5162 — Abstract Objective To compare the safety and efficacy of hysteroscopic sterilization with the “Essure” device with laparoscopic sterilization in a large, all-inclusive, state cohort. Design Population based…

La piramide de la medicina basada en la evidencia es “overly-simplistic”

“overly simplistic” : tautology — http://www.nationalgeographic.com.es/articulo/historia/grandes_reportajes/8518/piramide_djoser.html — Read more: Pyramid of evidence-based medicine: hierarchical levels of study designs (strength of evidence) Clinical trials, observational studies and meta-analysis Evidence based medicine (EBM) not evidence-based: medicine is broken. Tensile Integrity Structures Update: Data (i.e., evidence) about evidence based medicine. figshare

[ . . . ] In conclusion, evidence based methods, including the funnel plot, should be evidence based. If treatment decisions are made on the basis of misleading methodological tests, the costs to patients and society could be high. Decisions guided by the easy assurance of a symmetrical funnel plot may overlook serious bias. Equally, it may be misleading to discredit and abandon valid evidence simply because of an asymmetrical funnel plot. The prevention of publication bias is much more desirable than any diagnostic or corrective analysis.

Lau Joseph, Ioannidis John P A, Terrin Norma, SchmidChristopher H, Olkin Ingram. The case of the misleading funnel plot

“Return of Electro-Cures Exposes Psychiatry’s Weakness” – @sciam |HT @RsISK

“Transcranial magnetic stimulation is becoming an increasingly popular treatment for depression in spite of a lack of objective evidence of effectiveness. Illustration: National Institute of Mental Health.” The big promise & poor performance of electro-cures for the mind, by @Horganism With @DrDavidHealy on limits of ECT http://t.co/I15RSs3NR4 — Data Based Medicine (@RxISK) August 6, 2015 — Addendum:…

Dear @MassMedical:

Why an ostrich – without clothes – bury their head in the sand instead of enjoying the beautiful sunshine? You know @MassMedical what is the problem after stamping out dissent? Re: Backfire http://t.co/8yDoU3AJCT cc @mllangan1 @NHSwhistleblowr — Le coup de sifflet (@Colombia_Medica) June 8, 2015 #MassachusettsMedicalSociety #Ostrich Head in sand! Does #MMS represent #doctors or for profit…

Clinical trials, observational studies and meta-analysis

0. Background Human pharmacology is a non-linear science created by multiple variables at different levels of complexity: 1. Drug effects at molecular and cellular levels: drug-receptor interaction (pharmacodynamics) and drug disposition (pharmacokinetics) 2. Effects of drugs on human health and disease: safety, efficacy, and effectiveness 3. Effects of drugs in the society: economic aspects (i.e.,…

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